Endothelium-independent vasorelaxant effect of a Berberis orthobotrys root extract via inhibition of phosphodiesterases in the porcine coronary artery

Author:

Alamgeer ,Chabert P.,Akhtar M.S.,Jabeen Q.,Delecolle J.,Heintz D.,Garo E.,Hamburger M.,Auger C.,Lugnier C.ORCID,Kim H.-J.,Oak M.-H.,Schini-Kerth V.B.

Funder

Ministry of Science, ICT

Future Planning of Korea

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference33 articles.

1. Antihypertensive Activity of Aqueous-Methanol Extract of Berberis Orthobotrys Bien Ex Aitch in Rats;Alamgeer;Trop. J. Pharm. Res.,2013

2. Mechanism of nitric oxide-induced vasodilatation: refilling of intracellular stores by sarcoplasmic reticulum Ca2+ ATPase and inhibition of store-operated Ca2+ influx;Cohen;Circ. Res.,1999

3. The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3’:5′ cAMP-dependent protein kinase;Conti;J. Biol. Chem.,1981

4. Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials;Derosa;Expert Opin. Biol. Ther.,2012

5. Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway;Eckly;Br. J. Pharmacol.,1994

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