Affiliation:
1. UCSI University Malaysia Faculty of Pharmaceutical Sciences Kuala Lumpur Malaysia
2. GLA University Institute of Pharmaceutical Research Mathura India
Abstract
Abstract:
Phosphodiesterases (PDEs) function to hydrolyze intracellular cyclic adenosine monophosphate
(cAMP) and cyclic guanosine monophosphate (cGMP), regulating a variety of intracellular
signal transduction and physiological activities. PDEs can be divided into 11 families
(PDE1~11) and the diversity and complex expression of PDE family genes suggest that different
subtypes may have different mechanisms. PDEs are involved in various disease pathologies such
as inflammation, asthma, depression, and erectile dysfunction and are thus targets of interest for
several drug discovery campaigns. Natural products have always been an important source of bioactive
compounds for drug discovery, over the years several natural compounds have shown potential
as inhibitors of PDEs. In this article, phosphodiesterase inhibitors of natural origin have been
reviewed with emphasis on their chemistry and biological activities.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry