Identification of a novel BACE1 inhibitor, timosaponin A-III, for treatment of Alzheimer's disease by a cell extraction and chemogenomics target knowledgebase-guided method
Author:
Funder
National Natural Science Foundation of China
Publisher
Elsevier BV
Subject
Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine
Reference45 articles.
1. Flavanone glycosides inhibit beta-site amyloid precursor protein cleaving enzyme 1 and cholinesterase and reduce Abeta aggregation in the amyloidogenic pathway;Ali;Chem. Biol. Interact.,2019
2. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease;Caccamo;Proc. Natl. Acad. Sci. U. S. A.,2010
3. Effect of qingxin kaiqiao formula and saponin on learning and memory abilities and expression of apoptosis signal transducers Abeta and betaAPP in AD rat brain;Chu;China J. Chin. Mater. Med.,2012
4. The determination of enzyme inhibitor constants;Dixon;Biochem. J.,1953
5. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice;Evans;Neurobiol. Aging.,2019
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Molecular Docking for Virtual Screening of Potential Active Ingredients in Chinese Medicines;Quality Control of Chinese Medicines;2024
2. In vitro blood brain barrier permeability study of four main active ingredients from Alpiniae oxyphyllae fructus;Journal of Pharmaceutical and Biomedical Analysis;2023-10
3. BACE-1 Inhibitors Targeting Alzheimer's Disease;Current Alzheimer Research;2023-03
4. Current study on diagnosis and treatment of Alzheimer’s disease by targeting amyloid b-protein;Folia Neuropathologica;2023
5. The role of autophagy in the treatment of osteoporosis by Chinese medicines (natural);Traditional Medicine Research;2023
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3