Benzoquinones from Cyperus spp. trigger IRE1α-independent and PERK-dependent ER stress in human stomach cancer cells and are novel proteasome inhibitors

Author:

Ribeiro Vera,Andrade Paula B.ORCID,Valentão PatríciaORCID,Pereira David M.ORCID

Funder

FCT

MCTES

Programa de Cooperación Interreg V A España – Portugal

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference31 articles.

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3. Recent patents on proteasome inhibitors of natural origin;Correia da Silva;Recent Pat. Anti-Cancer Drug Discov.,2017

4. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule;Cross;Proc. Natl. Acad. Sci. U.S.A.,2012

5. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum;da Silva;J. Steroid Biochem. Mol. Biol.,2017

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