Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

Author:

Franco Caio H.,Warhurst David C.,Bhattacharyya Tapan,Au Ho Y.A.ORCID,Le Hai,Giardini Miriam A.ORCID,Pascoalino Bruno S.,Torrecilhas Ana Claudia,Romera Lavinia M.D.,Madeira Rafael PedroORCID,Schenkman SergioORCID,Freitas-Junior Lucio H.,Chatelain Eric,Miles Michael A.,Moraes Carolina B.

Funder

DNDi

Institut Pasteur Korea

Federal Ministry of Education and Research (KfW-BMBF)/Germany

Médecins Sans Frontières (Doctors without Borders)/International

Department for International Development (DFID), UK

Directorate-General for International Cooperation (DGIS), The Netherlands

Swiss Agency for Development and Cooperation

National Research Foundation of Korea

Publisher

Elsevier BV

Subject

Pharmacology (medical),Infectious Diseases,Pharmacology,Parasitology

Reference67 articles.

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2. New mechanisms of drug resistance in parasitic protozoa;Borst;Annu. Rev. Microbiol.,1995

3. Cloning and analysis of Trypanosoma cruzi lanosterol 14α-demethylase;Buckner;Mol. Biochem. Parasitol.,2003

4. Induction of resistance to azole drugs in Trypanosoma cruzi;Buckner;Antimicrob. Agents Chemother.,1998

5. Growth and differentiation in Trypanosoma cruzi. I. Origin of metacyclic trypanosomes in liquid media;Camargo;Rev. Inst. Med. Trop. Sao Paulo,1964

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