Melatonin enhances anti-tumor immunity by targeting macrophages PD-L1 via exosomes derived from gastric cancer cells

Author:

Wang KaifangORCID,Cai Rong,Fei Shuting,Chen Xuzheng,Feng Sisi,Zhang Lulu,Liu Hui,Zhang Zhiguang,Song Jun,Zhou Ruixiang

Publisher

Elsevier BV

Subject

Endocrinology,Molecular Biology,Biochemistry

Reference55 articles.

1. Immunomodulation: an immune regulatory mechanism in carcinoma therapeutics;Alsaffar;Int. Immunopharm.,2021

2. Combination of melatonin with paclitaxel reduces the TLR4-mediated inflammatory pathway, PD-L1 levels, and survival of ovarian carcinoma cells;Barbosa Gaiotte;Melatonin Res.,2022

3. Tumour necrosis factor, interferon-gamma and interleukins as predictive markers of antiprogrammed cell-death protein-1 treatment in advanced non-small cell lung cancer: a pragmatic approach in clinical practice;Boutsikou;Therapeutic Adv. Med. Oncol.,2018

4. Melatonin downregulates PD-L1 expression and modulates tumor immunity in KRAS-mutant non-small cell lung cancer;Chao;Int. J. Mol. Sci.,2021

5. Cancer cell-derived exosomal circUSP7 induces CD8(+) T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC;Chen;Mol. Cancer,2021

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