Role of melatonin in carcinogenesis and metastasis: From mechanistic insights to intermeshed networks of noncoding RNAs

Author:

Lin Xiukun1,Qureshi Muhammad Zahid2,Tahir Fatima3,Yilmaz Seher4,Romero Mirna Azalea5,Attar Rukset6,Farooqi Ammad A.7ORCID

Affiliation:

1. College of Marine Sciences Beibu Gulf University Qinzhou Guangxi China

2. Department of Environment and Natural Resources, College of Agriculture and Food Qassim University Buraidah Saudi Arabia

3. Rashid Latif Medical University Lahore Pakistan

4. Department of Anatomy, Faculty of Medicine Yozgat Bozok University Yozgat Turkey

5. Facultad de Medicina, Universidad Autónoma de Guerrero Laboratorio de Investigación Clínica Acapulco Guerrero México

6. Department of Obstetrics and Gynecology Yeditepe University Hospital Istanbul Turkey

7. Institute of Biomedical and Genetic Engineering (IBGE) Islamabad Pakistan

Abstract

AbstractIn recent years, seminal studies have been devoted to unraveling the puzzling mysteries associated with the cancer preventive/inhibitory role of melatonin. Our current knowledge of the translational mechanisms and the detailed structural insights have highlighted the characteristically exclusive role of melatonin in the inhibition of carcinogenesis and metastatic dissemination. This mini‐review outlines recent discoveries related to mechanistic role of melatonin in prevention of carcinogenesis and metastasis. Moreover, another exciting facet of this mini‐review is related to phenomenal breakthroughs linked with regulation of noncoding RNAs by melatonin in wide variety of cancers.

Publisher

Wiley

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