Relative involvement of three 17β-hydroxysteroid dehydrogenases (types 1, 7 and 12) in the formation of estradiol in various breast cancer cell lines using selective inhibitors

Author:

Laplante Yannick,Rancourt Claudine,Poirier Donald

Publisher

Elsevier BV

Subject

Endocrinology,Molecular Biology,Biochemistry

Reference56 articles.

1. 17beta-Hydroxysteroid dehydrogenase type 1 and type 2 in ductal carcinoma in situ and intraductal proliferative lesions of the human breast;Ariga;Anticancer Res.,2000

2. Bellavance, E., 2004. Étude structure activité menant au développement d’inhibiteurs sélectifs de la 17β-hydroxystéroïde déshydrogénase type 7. M.Sc. Thesis. Université Laval, Québec City, Canada, pp. 56–111.

3. First inhibitors of the steroidogenic enzyme type 7 17β-hydroxysteroid dehydrogenase;Bellavance;Lett. Drug Des. Discov.,2004

4. Inhibition of type 2 17β-hydroxysteroid dehydrogenase by estradiol derivatives bearing a lactone on the D-ring: structure–activity relationships;Bydal;Steroids,2004

5. Bydal, P., Luu-The, V., Labrie, F., Poirier, D., in press. Steroidal lactones as inhibitors of 17β-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. Eur. J. Med. Chem., doi:10.1016/j.ejmech.2008.03.020.

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