Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity-Reference-Cited by-同舟云学术

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Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity

Published:2018-01 Issue: Volume:144 Page:128-136
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Cen Juan,Guo Huiyan,Hong Chen,Lv Jianwu,Yang Yacheng,Wang Ting,Fang Dong,Luo Wen^ORCID,Wang Chaojie

Funder

National Natural Science Foundation of China

Foundation for University Key Teacher by Educational Commission of Henan Province

Educational Commission of Henan Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference31 articles.

1. Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents;Shaik;Eur. J. Med. Chem.,2016

2. Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives;Khunnawutmanotham;Bioorg. Chem.,2016

3. Toxic effects of tacrine on primary hepatocytes and liver epithelial cells in culture;Lagadic-Gossmann;Cell Biol. Toxicol.,1998

4. Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease;Bolognesi;J. Med. Chem.,2007

5. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease;Chao;Bioorg. Med. Chem. Lett.,2012

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