Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity
Author:
Funder
National University of Singapore
National Medical Council
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference29 articles.
1. Designed multiple ligands. An emerging drug discovery paradigm;Morphy;J. Med. Chem.,2005
2. The benefits of the multi-target approach in drug design and discovery;Espinoza-Fonseca;Bioorg Med. Chem.,2006
3. Designed multiple ligands for cancer therapy;O'Boyle;Curr. Med. Chem.,2011
4. The renewed potential for folate antagonists in contemporary cancer chemotherapy;Berman;J. Med. Chem.,1991
5. DNA and RNA synthesis: antifolates;Kompis;Chem. Rev.,2005
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