Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors

Published:2016-07 Issue: Volume:117 Page:47-58
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhan Wenhu,Xu Lei,Dong Xiaowu,Dong Jun,Yi Xiao,Ma Xiaodong,Qiu Ni,Li Jia,Yang Bo,Zhou Yubo,Hu Yongzhou

Funder

Zhejiang province Provincial Natural Science Foundation of China

Program for Zhejiang Leading Team of S&T Innovation

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference39 articles.

1. Targeting the phosphoinositide 3-kinase pathway in cancer;Liu;Nat. Rev. Drug Discov.,2009

2. AKT/PKB signaling: navigating downstream;Manning;Cell,2007

3. The Akt pathway: molecular targets for anti-cancer drug development;Mitsiades;Curr. Cancer Drug Tar,2004

4. Activation of AKT kinases in cancer: implications for therapeutic targeting;Bellacosa;Adv. Cancer Res.,2005

5. Amplification of AKT2 in human pancreatic cancer cells and inhibition of ATK2 expression and tumorigenicity by antisense RNA;Cheng;Proc. Natl. Acad. Sci. U. S. A.,1996

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