Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense-Reference-Cited by-同舟云学术

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Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense

Published:2018-04 Issue: Volume:150 Page:385-402
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Ebiloma Godwin U.,Ayuga Teresa Díaz,Balogun Emmanuel O.,Gil Lucía Abad,Donachie Anne,Kaiser Marcel,Herraiz Tomás,Inaoka Daniel K.,Shiba Tomoo,Harada Shigeharu,Kita Kiyoshi,de Koning Harry P.^ORCID,Dardonville Christophe^ORCID

Funder

Spanish Ministerio de Economia y Competitividad

TDR

Special Programme for Research and Training in Tropical Diseases (

UNICEF

UNDP

World Bank

WHO)

TET-Fund

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference46 articles.

1. The alternative oxidases: simple oxidoreductase proteins with complex functions;Young;Biochem. Soc. Trans.,2013

2. The trypanosomiases;Barrett;Lancet,2003

3. The animal trypanosomiases and their chemotherapy - a review;Giordani;Parasitol. Int.,2016

4. Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies;Nakamura;Parasitol. Int.,2010

5. Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol;Yabu;Parasitol. Int.,2006

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Alternative Oxidase: From Molecule and Function to Future Inhibitors;ACS Omega;2024-03-04

2. Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites;Journal of Medicinal Chemistry;2023-09-20

3. The Activity of Red Nigerian Propolis and Some of Its Components against Trypanosoma brucei and Trypanosoma congolense;Molecules;2023-01-07

4. Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?;Biochemical Journal;2022-06-24

5. Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure–Activity Relationship Studies;ACS Medicinal Chemistry Letters;2022-01-28

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