Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure–Activity Relationship Studies-Reference-Cited by-同舟云学术

Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure–Activity Relationship Studies

Published:2022-01-28 Issue:2 Volume:13 Page:312-318
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Cisneros David¹,Cueto-Díaz Eduardo J.¹^ORCID,Medina-Gil Tania¹,Chevillard Rebecca¹,Bernal-Fraile Teresa¹,López-Sastre Ramón¹,Aldfer Mustafa M.²,Ungogo Marzuq A.²,Elati Hamza A. A.²^ORCID,Arai Natsumi³,Otani Momoka³,Matsushiro Shun³,Kojima Chiaki³,Ebiloma Godwin U.³⁴,Shiba Tomoo³,de Koning Harry P.²^ORCID,Dardonville Christophe¹^ORCID

Affiliation:

1. Instituto de Química Médica, IQM−CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain

2. Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom

3. Graduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan

4. School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, United Kingdom

Funder

Ministerio de Ciencia e Innovaci?n

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00717

Reference27 articles.

1. l-α-Glycerophosphate dehydrogenase, a component of an oxidase system in Trypanosoma rhodesiense

2. Properties of l-α-glycerophosphate oxidase and its role in the respiration of Trypanosoma rhodesiense

3. Respiration of Bloodstream Forms of the Parasite Trypanosoma brucei brucei Is Dependent on a Plant-like Alternative Oxidase

4. Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies

5. Alternative oxidase inhibitors: Mitochondrion-targeting as a strategy for new drugs against pathogenic parasites and fungi

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