Synthesis and biological evaluation of novel tetrahydroisoquinoline- C -aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of novel tetrahydroisoquinoline- C -aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes

Published:2016-05 Issue: Volume:114 Page:89-100
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Pan Xuan,Huan Yi,Shen Zhufang,Liu Zhanzhu

Funder

Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference25 articles.

1. ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors

2. EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA1c levels in db/db mice and prolongs the survival of stroke-prone rats

3. C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

4. Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antidiabetic Advancements In Silico: Pioneering Novel Heterocyclic Derivatives through Computational Design;Current Signal Transduction Therapy;2024-07

2. Exploring novel lead scaffolds for SGLT2 inhibitors: Insights from machine learning and molecular dynamics simulations;International Journal of Biological Macromolecules;2024-04

3. Recent developments on the synthesis of biologically active glycohybrids;Bioorganic Chemistry;2024-04

4. Biological Activities of Tetrahydroisoquinolines Derivatives;Journal of Organic and Pharmaceutical Chemistry;2023-06-03

5. Potential Therapeutic Targets for the management of Diabetes Mellitus Type 2;Current Medicinal Chemistry;2023-05-01

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