In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrPC to PrPSc-Reference-Cited by-同舟云学术

In silico studies and fluorescence binding assays of potential anti-prion compounds reveal an important binding site for prion inhibition from PrPC to PrPSc

Published:2015-02 Issue: Volume:91 Page:118-131
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Pagadala Nataraj S.^ORCID,Perez-Pineiro Rolando,Wishart David S.,Tuszynski Jack A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference48 articles.

1. Novel proteinaceous infectious particles cause scrapie;Prusiner;Science,1982

2. Prions;Prusiner;Proc. Natl. Acad. Sci. U. S. A.,1998

3. New inhibitors of scrapie associated prion protein formation in a library of 2000 drugs and natural products;Kocisko;J. Virol.,2003

4. Mimicking dominant negative inhibition of prion replication through structure-based drug design;Perrier;Proc. Natl. Acad. Sci. U. S. A.,2000

5. New series of anti-prion compounds: pyrazolone derivatives have the potent activity of inhibiting protease resistant prion protein accumulation;Kimata;J. Med. Chem.,2007

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Small Molecules with Anti-Prion Activity;Current Medicinal Chemistry;2020-10-08

2. In silico/in vitro screening and hit evaluation identified new phenothiazine anti-prion derivatives;European Journal of Medicinal Chemistry;2020-06

3. BMD42-2910, a Novel Benzoxazole Derivative, Shows a Potent Anti-prion Activity and Prolongs the Mean Survival in an Animal Model of Prion Disease;Experimental Neurobiology;2020-02-29

4. Potential Antiprion Drugs;Molecular Dynamics Analyses of Prion Protein Structures;2018

5. The compound (3-{5-[(2,5-dimethoxyphenyl)amino]-1,3,4-thiadiazolidin-2-yl}-5,8-methoxy-2H-chromen-2-one) inhibits the prion protein conversion from PrPC to PrPSc with lower IC50 in ScN2a cells;Bioorganic & Medicinal Chemistry;2017-10