Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation
Author:
Funder
University of South Australia
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference86 articles.
1. CDK8-novel therapeutic opportunities;Menzl;Pharmaceuticals,2019
2. Cyclin-dependent kinase 8: a new hope in targeted cancer therapy?;Philip;J. Med. Chem.,2018
3. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response;Bancerek;Immunity,2013
4. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover;Fryer;Mol. Cell,2004
5. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways;Alarcón;Cell,2009
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