Design and synthesis of 7-azaindole derivatives as potent CDK8 inhibitors for the treatment of acute myeloid leukemia-Reference-Cited by-同舟云学术

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Design and synthesis of 7-azaindole derivatives as potent CDK8 inhibitors for the treatment of acute myeloid leukemia

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Wang Yumeng¹,Lei Cencen¹,Wang Quan¹,Zhang Xingxing¹,Zhi Liping²,Liu Xinhua¹^ORCID

Affiliation:

1. School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, P. R. China

2. School of Health Management, Anhui Medical University Hefei, 230032, PR China

Abstract

A new compound exhibiting excellent inhibitory activity against CDK8 was discovered. The mechanism was explored.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00465E

Reference32 articles.

1. Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts

2. Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

3. Discovery and Development of Cyclin-Dependent Kinase 8 Inhibitors

4. Angel or Devil ? - CDK8 as the new drug target

5. Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3′,4′:3,4]benzo[1,2- d ]isothiazole derivatives

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