Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction-Reference-Cited by-同舟云学术

Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction

Published:2021-04 Issue: Volume:216 Page:113270
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Nakahara Kenji,Mitsuoka Yasunori,Kasuya Satoshi,Yamamoto Takahiko,Yamamoto Shiho,Ito Hisanori,Kido Yasuto,Kusakabe Ken-ichi^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

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4. In silico and in vitro analyses of a novel FoxO1 agonist reducing Aβ levels via downregulation of BACE1;CNS Neuroscience & Therapeutics;2023-03-09

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