Innovative C-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4-Reference-Cited by-同舟云学术

Innovative C-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4

Published:2021-08 Issue: Volume:220 Page:113496
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Paquin Alexis^ORCID,Oufqir Yassine,Sevrioukova Irina F.,Reyes-Moreno Carlos,Bérubé Gervais^ORCID

Funder

Canadian Institutes of Health Research

Canadian Cancer Society

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference45 articles.

1. Molecules that Changed the World: A Brief History of the Art and Science of Synthesis and its Impact on Society;Nicolaou,2008

2. A review on pharmacophoric designs of antiproliferative agents;Rana;Med. Chem. Res.,2015

3. Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids;Nepali;Eur. J. Med. Chem.,2014

4. Hybrid molecules: the privileged scaffolds for various pharmaceuticals;Shaveta;Eur. J. Med. Chem.,2016

5. An overview of molecular hybrids in drug discovery;Bérubé;Expet Opin.Drug Discov.,2016

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