Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors-Reference-Cited by-同舟云学术

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Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors

Published:2016-03 Issue: Volume:110 Page:181-194
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Bouckaert Charlotte,Serra Silvia,Rondelet Grégoire,Dolušić Eduard,Wouters Johan,Dogné Jean-Michel,Frédérick Raphaël,Pochet Lionel

Funder

F.R.S.-FNRS

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference52 articles.

1. Triggers, targets and treatments for thrombosis;Mackman;Nature,2008

2. Factor XI and contact activation as targets for antithrombotic therapy;Gailani;J. Thromb. Haemost.,2015

3. The procoagulant and proinflammatory plasma contact system;Renne;Semin. Immunopathol.,2012

4. Defective thrombus formation in mice lacking coagulation factor XII;Renne;J. Exp. Med.,2005

5. Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis;Kleinschnitz;J. Exp. Med.,2006

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2. Dual Inhibition of Factor XIIa and Factor XIa Produces a Synergistic Anticoagulant Effect;Journal of Cardiovascular Pharmacology;2024-07

3. Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation;Journal of Medicinal Chemistry;2024-06-24

4. Structural properties of newly 4,7-dihydroxycoumarin derivatives as potential inhibitors of XIIa, Xa, IIa factors of coagulation;Journal of Molecular Structure;2024-02

5. Coumarins as factor XIIa inhibitors: Potency and selectivity improvements using a fragment-based strategy;European Journal of Medicinal Chemistry;2023-11

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