Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold-Reference-Cited by-同舟云学术

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Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold

Published:2019-05 Issue: Volume:170 Page:276-289
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Stepanek Ondrej,Hin Niyada,Thomas Ajit G.,Dash Ranjeet P.,Alt Jesse,Rais Rana,Rojas Camilo,Slusher Barbara S.,Tsukamoto Takashi^ORCID

Funder

NIH

Johns Hopkins Drug Discovery

Institute of Organic Chemistry and Biochemistry (IOCB) of the Czech Academy of Sciences

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference40 articles.

1. Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes;Shamseddine;Adv. Biol. Regul,2015

2. Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation;Airola;Proc. Natl. Acad. Sci. U. S. A.,2017

3. The enzymatic sphingomyelin to ceramide conversion increases the shear membrane viscosity at the air-water interface;Catapano;Adv. Colloid Interface Sci.,2017

4. Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters;Eich;Sci. Rep.,2016

5. Ceramide-enriched membrane domains;Bollinger;Biochim. Biophys. Acta,2005

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2. Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold;European Journal of Medicinal Chemistry;2023-11

3. Regulation and function of neutral sphingomyelinase 2;Phospholipases in Physiology and Pathology;2023

4. Molecular dynamics articulated multilevel virtual screening protocol to discover novel dual PPAR α/γ agonists for anti-diabetic and metabolic applications;Molecular Diversity;2022-11-28

5. Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation;International Journal of Molecular Sciences;2022-11-11

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