Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors

Author:

Grover Jagdeep,Kumar Vivek,Singh Vikram,Bairwa Khemraj,Sobhia M. Elizabeth,Jachak Sanjay M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference24 articles.

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2. Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis;Hamberg;Proceedings of the National Academy of Sciences of the United States of America,1973

3. Structural and functional basis of cyclooxygenase inhibition;Blobaum;Journal of Medicinal Chemistry,2007

4. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic;Warner;FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology,2004

5. Risk of cardiovascular events associated with selective COX-2 inhibitors;Mukherjee;JAMA: the Journal of the American Medical Association,2001

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