Hyposterolactone A, a 3<i>α</i>‐Hydroxy Steroidal Lactone from the Deep‐Sea‐Derived Fungus<i>Hypocrea</i>sp. ZEN14-Reference-Cited by-同舟云学术

Hyposterolactone A, a 3α‐Hydroxy Steroidal Lactone from the Deep‐Sea‐Derived FungusHypocreasp. ZEN14

Published:2023-06-20 Issue:7 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Xu Lin¹,Ma Hua‐Bin²,Wu Taizong¹³,Liu Li‐Fang¹,Xie Ming‐Min¹,Hu Man‐Yi¹,Gai Ying‐Bao¹,Zhong Tian‐Hua¹,Yang Xian‐Wen¹^ORCID

Affiliation:

1. Key Laboratory of Marine Biogenetic Resources Third Institute of Oceanography Ministry of Natural Resources 184 Daxue Road Xiamen 361005 China

2. Central Laboratory the First Affiliated Hospital Fujian Medical University Fuzhou 350005 China

3. Institute for Molecular Bioscience University of Queensland Brisbane 4072 Australia

Abstract

AbstractChemical investigation of the deep‐sea‐derived fungusHypocreasp. ZEN14 afforded a new 3α‐hydroxy steroidal lactone, hyposterolactone A (1) and 25 known secondary metabolites (2–26). The structure of the new compound was established by detailed spectroscopic analysis, electronic circular dichroism (ECD) calculation as well as aJ‐based configuration analysis. Compound10showed potent cytotoxicity against Huh7 and Jurkat cells with IC50values of 1.4 μM and 6.7 μM, respectively.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202300753

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