Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E2 synthase-1 enzyme (mPGES-1)

Author:

Lauro Gianluigi,Strocchia Maria,Terracciano Stefania,Bruno Ines,Fischer Katrin,Pergola Carlo,Werz Oliver,Riccio Raffaele,Bifulco Giuseppe

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference28 articles.

1. Cyclooxygenase-2: a therapeutic target;Turini;Annual Review of Medicine,2002

2. The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis;McCoy;The Journal of Clinical Investigation,2002

3. mPGES-1 as a target for cancer suppression;Nakanishi;Biochimie,2010

4. Membrane prostaglandin E synthase-1: a novel therapeutic target;Samuelsson;Pharmacological Reviews,2007

5. Risk of cardiovascular events associated with selective COX-2 inhibitors;Mukherjee;Journal of the American Medical Association,2001

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