2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents-Reference-Cited by-同舟云学术

2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents

Published:2018-05 Issue: Volume:151 Page:363-375
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Chiaramonte Niccolò,Bua Silvia,Ferraroni Marta,Nocentini Alessio,Bonardi Alessandro,Bartolucci Gianluca,Durante Mariaconcetta,Lucarini Laura,Chiapponi Donata,Dei Silvia,Manetti Dina^ORCID,Teodori Elisabetta^ORCID,Gratteri Paola,Masini Emanuela,Supuran Claudiu T.^ORCID,Romanelli Maria Novella^ORCID

Funder

University of Florence

European Synchrotron Radiation Facility

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference53 articles.

1. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators;Supuran;Nat. Rev. Drug Discov.,2008

2. Carbonic anhydrases: an overview;Supuran,2015

3. Structure-based drug discovery of carbonic anhydrase inhibitors;Supuran;J. Enzym. Inhib. Med. Chem.,2012

4. Carbonic anhydrase inhibitors;Supuran;Bioorg. Med. Chem. Lett,2010

5. Discovery of novel inhibitors for the treatment of glaucoma;Cholkar;Expet Opin. Drug Discov.,2015

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bioactivity, cytotoxicity, and molecular modeling studies of novel sulfonamides as dual inhibitors of carbonic anhydrases and acetylcholinesterase;Journal of Molecular Liquids;2024-09

2. A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments;European Journal of Medicinal Chemistry;2024-08

3. Chemistry of heterocycles as carbonic anhydrase inhibitors: A pathway to novel research in medicinal chemistry review;Archiv der Pharmazie;2024-04-29

4. Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma;Journal of Medicinal Chemistry;2024-01-11

5. Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations;PeerJ;2022-10-07