Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo-Reference-Cited by-同舟云学术

Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo

Published:2022-03 Issue: Volume:232 Page:114187
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Bin Huachao,Chen Pei,Wu Ming,Wang Falu,Lin Guifeng,Pan Shulei,Liu Jingming,Mu Bo,Nan Jinshan,Huang Qiao,Li Linli,Yang Shengyong^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference45 articles.

1. ATR: an essential regulator of genome integrity;Cimprich;Nat. Rev. Mol. Cell Biol.,2008

2. ATR signalling: more than meeting at the fork;Nam;Biochem. J.,2011

3. Replication stress and cancer;Gaillard;Nat. Rev. Cancer,2015

4. DNA replication stress and cancer: cause or cure?;Taylor;Future Oncol.,2016

5. RPA-binding protein ETAA1 is an ATR activator involved in DNA replication stress response;Lee;Curr. Biol.,2016

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An update on small molecule compounds targeting synthetic lethality for cancer therapy;European Journal of Medicinal Chemistry;2024-11

2. Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies;Journal of Medicinal Chemistry;2024-07-25

3. Ataxia telangiectasia and Rad3-related protein inhibitors;Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy;2024

4. Discovery of Thieno[3,2-d]pyrimidine derivatives as potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) kinase;European Journal of Medicinal Chemistry;2023-07

5. Design, synthesis, and biological evaluation of pyrido[3,2-d]pyrimidine derivatives as novel ATR inhibitors;Bioorganic Chemistry;2023-07