Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer

Published:2020-11 Issue: Volume:205 Page:112648
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Yao Dahong,Li Chenyang,Jiang Jin,Huang Jian,Wang Jinhui,He Zhendan,Zhang Jin

Funder

National Natural Science Foundation of China

National Key R & D Program of China

Postdoctoral Research Foundation of China

Foundation Committee of basic and applied basic research of Guangdong Province

Shenzhen Natural Science Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference32 articles.

1. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders;Falkenberg;Nat. Rev. Drug Discov.,2014

2. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer;Johnstone;Nat. Rev. Drug Discov.,2002

3. Lysine acetylation goes global: from epigenetics to metabolism and therapeutics;Ali;Chem. Rev.,2018

4. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond;Verdin;Nat. Rev. Mol. Cell Biol.,2015

5. Histone deacetylase function in CD4(+) T cells;Ellmeier;Nat. Rev. Immunol.,2018

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1. Discovery and Development of HDAC Inhibitors: Approaches for the Treatment of Cancer a Mini-review;Current Drug Discovery Technologies;2024-11

2. An assessment of crucial structural contributors of HDAC6 inhibitors through fragment-based non-linear pattern recognition and molecular dynamics simulation approaches;Computational Biology and Chemistry;2024-06

3. In-silico design of novel potential HDAC inhibitors from indazole derivatives targeting breast cancer through QSAR, molecular docking and pharmacokinetics studies;Computational Biology and Chemistry;2024-06

4. Design, synthesis, biological evaluation and molecular docking study of novel chalcone-based hydroxamic acids possessing a central 2, 4-dimethy pyrrole linker as potential HDAC (Histone Deacetylase) inhibitors and anticancer agents;Journal of Molecular Structure;2024-06

5. Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation;Future Medicinal Chemistry;2024-04-16

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