Design, synthesis, biological evaluation and molecular docking study of novel chalcone-based hydroxamic acids possessing a central 2, 4-dimethy pyrrole linker as potential HDAC (Histone Deacetylase) inhibitors and anticancer agents

Author:

Yousefian Mozhdeh,Hashemi Maryam,Eskandarpour VahidORCID,Hadizadeh FarzinORCID,Zarghi Afshin,Ghodsi Razieh

Funder

Mashhad University of Medical Sciences

Publisher

Elsevier BV

Reference36 articles.

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2. Histone deacetylase inhibitors as anticancer drugs;Eckschlager;Int. J. Mol. Sci.,2017

3. Highly compacted chromatin formed in vitro reflects the dynamics of transcription activation in vivo;Li;Mol. Cell,2010

4. Epigenetics: the Science of Change;Weinhold,2006

5. Epigenetics—An epicenter of gene regulation: histones and histone-modifying enzymes;Biel;Angew. Chem. Int. Ed.,2005

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