Selective targeting of the αC and DFG-out pocket in p38 MAPK-Reference-Cited by-同舟云学术

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Selective targeting of the αC and DFG-out pocket in p38 MAPK

Published:2020-12 Issue: Volume:208 Page:112721
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Röhm Sandra,Schröder Martin,Dwyer Jessica E.,Widdowson Caroline S.,Chaikuad Apirat^ORCID,Berger Benedict-Tilman^ORCID,Joerger Andreas C.,Krämer Andreas,Harbig Jule,Dauch Daniel,Kudolo Mark,Laufer Stefan^ORCID,Bagley Mark C.^ORCID,Knapp Stefan^ORCID

Funder

AbbVie

Bayer Pharma AG

Boehringer Ingelheim

Canada Foundation for Innovation

Eshelman Institute for Innovation

Genome Canada

Innovative Medicines Initiative

Janssen

Merck KGaA Darmstadt Germany

MSD

Novartis Pharma AG

Ontario Ministry of Economic Development and Innovation

Pfizer

São Paulo Research Foundation-FAPESP

Takeda

Wellcome

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference53 articles.

1. Mammalian mapk signal transduction pathways activated by stress and inflammation: a 10-year update;Kyriakis;Physiol. Rev.,2012

2. A comprehensive structural overview of p38α mitogen-activated protein kinase in complex with atp-site and non-atp-site binders;Astolfi;ChemMedChem,2018

3. Pathway to the clinic: inhibition of P38 map kinase. A review of ten chemotypes selected for development;Goldstein;Curr. Top. Med. Chem.,2005

4. Fast iterative synthetic approach toward identification of novel highly selective p38 MAP kinase inhibitors;Röhm;J. Med. Chem.,2019

5. Exploration of type II binding mode: a privileged approach for kinase inhibitor focused drug discovery?;Zhao;ACS Chem. Biol.,2014

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