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Antitumor activity and structure-activity relationship of heparanase inhibitors: Recent advances

  • Published:2020-05 Issue: Volume:193 Page:112221
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Fu Kaishuo,Bai Zhifeng,Chen Lanlan,Ye Wenchong,Wang Meizhu,Hu Jiliang,Liu Chunhui,Zhou Wen

Funder

National Natural Science Foundation of China

General scientific research project of Guangzhou

“Climbing” progress of Guangdong province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference155 articles.

1. Opposing functions of heparanase-1 and heparanase-2 in cancer progression;Vlodavsky;Trends Biochem. Sci.,2018

2. Structural characterization of human heparanase reveals insights into substrate recognition;Wu;Nat. Struct. Mol. Biol.,2015

3. Identification of active-site residues of the pro-metastatic endoglycosidase heparanase;Hulett;Biochemistry,2000

4. Heparanase in health and disease: the neglected housekeeper of the cell;Shu;Atherosclerosis,2019

5. Role of heparanase in tumor progression: molecular aspects and therapeutic options;Masola;Semin. Canc. Biol.,2019

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