Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation

Author:

Li Maolin,Ye Wenchong,Fu Kaishuo,zhou Cui,Shi Yonghui,Huang Weiping,Chen Wenming,Hu Jiliang,Jiang Zhilin,Zhou Wen

Funder

National Science Foundation of China

General Scientific Research Project of Guangzhou

“Climbing” Progress of Guangdong Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference31 articles.

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2. Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors;Kunimoto;Canc. Res.,1987

3. DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition;Pommier;Chem. Rev.,2009

4. Effects of topotecan on the proliferation and apopotosis of human hepatocarcinoma cell line HepG2 in vitro;Tian;Chongqing Med. J.,2003

5. Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT);Leu;J. Med. Chem.,1999

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