Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor-Reference-Cited by-同舟云学术

Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor

Published:2018-10 Issue: Volume:158 Page:896-916
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Wang Beilei,Wu Jiaxin,Wu Yun,Chen Cheng,Zou Fengming,Wang Aoli,Wu Hong,Hu Zhenquan,Jiang Zongru,Liu Qingwang,Wang Wei,Zhang Yicong,Liu Feiyang,Zhao Ming,Hu Jie,Huang Tao,Ge Juan,Wang Li,Ren Tao,Wang Yuxin,Liu Jing^ORCID,Liu Qingsong^ORCID

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Major Science and Technology Program of Anhui Province

China Postdoctoral Science Foundation

Natural Science Foundation of Anhui Province

Frontier Science Key Research Program of CAS

National Program for Support of Top-Notch Young Professionals

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine