The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy-Reference-Cited by-同舟云学术

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The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy

Published:2018-11 Issue: Volume:159 Page:1-9
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Liao Guochao,Yang Deying,Ma Leilei,Li Wenwei,Hu Liqin,Zeng Liming,Wu Peng,Duan Lixin,Liu Zhongqiu

Funder

National Natural Science Foundation of China

The Department of Science and Technology of Guangdong Province, China

Department of education of Guangdong Province, China

The Science and Technology Planning Program of Guangzhou City, China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference48 articles.

1. Hot spot-based design of small-molecule inhibitors for protein–protein interactions;Guo;Bioorg. Med. Chem. Lett.,2014

2. Oncogenic protein interfaces: small molecules, big challenges;Nero;Nat. Rev. Canc.,2014

3. Small-molecule inhibitors of the MDM2–p53 protein–protein interaction (MDM2 inhibitors) in clinical trials for cancer treatment;Zhao;J. Med. Chem.,2015

4. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2;Vassilev;Science,2004

5. Unravelling mechanisms of p53-mediated tumour suppression;Bieging;Nat. Rev. Canc.,2014

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