Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration-Reference-Cited by-同舟云学术

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Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration

Published:2019-12 Issue: Volume:183 Page:111694
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Cao Hengyi,Zhu Guangya,Sun Lin,Chen Ge,Ma Xinxin,Luo Xiao,Zhu Jidong

Funder

National Key R&D Program of China

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference25 articles.

1. Altered metabolite levels in cancer: implications for tumour biology and cancer therapy;Sullivan;Nat. Rev. Cancer,2016

2. Isocitrate dehydrogenase mutation and ( R )-2-Hydroxyglutarate: from basic discovery to therapeutics development;Dang;Annu. Rev. Biochem.,2017

3. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate;Dang;Nature,2009

4. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate;Ward;Cancer Cell,2010

5. Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers;Kang;Int. J. Cancer,2009

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1. Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents;European Journal of Medicinal Chemistry;2023-10

2. Challenges for the development of mutant isocitrate dehydrogenases 1 inhibitors to treat glioma;European Journal of Medicinal Chemistry;2023-09

3. Method for the Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones via Ligand-Free Copper-Catalyzed Cascade Reaction;Synthesis;2023-06-14

4. Visible‐Light‐Promoted Fluoroalkylative Cyclization of N‐Allyl‐4,5‐dihydro‐3H‐1‐benzazepin‐2‐amines: Effective Synthesis of Fluoroalkylated Imidazobenzazepines;ChemistrySelect;2023-04-04

5. Mutated Isocitrate Dehydrogenase (mIDH) as Target for PET Imaging in Gliomas;Molecules;2023-03-23

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