Affiliation:
1. Institute of Organic Chemistry National Academy of Sciences of Ukraine Akademika Kuharya str. 5 Kyiv 02094 Ukraine
2. National Pedagogical Dragomanov University Pirogova str. 9 Kyiv 01601 Ukraine
3. SSI “Institute for Single Crystals” National Academy of Science of Ukraine Nauky Ave. 60 Kharkiv 61001 Ukraine
Abstract
AbstractA new preparatively convenient approach to the synthesis of biopromising 1‐fluoroalkyl‐substituted 2,4,5,6‐tetrahydro‐1H‐imidazo[1,2‐a][1]benzazepines has been developed, based on the chemoselective photoreduction‐catalyzed fluoroalkylation cyclization of N‐allyl‐4,5‐dihydro‐3H‐1‐benzazepin‐2‐amines in the presence of fluorescein as an organocatalyst. The use of comparatively inexpensive perfluoroalkyl iodides (RfI), mild reaction conditions and a wide range of substituents introduced make this method very attractive for the preparation of imidazobenzazepines with a variety of fluorinated moieties.