Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme-Reference-Cited by-同舟云学术

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Published:2015-11 Issue: Volume:105 Page:274-288
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Sestito Simona,Nesi Giulia,Daniele Simona,Martelli Alma,Digiacomo Maria,Borghini Alice,Pietra Daniele,Calderone Vincenzo,Lapucci Annalina,Falasca Marco,Parrella Paola,Notarangelo Angelantonio,Breschi Maria C.,Macchia Marco,Martini Claudia,Rapposelli Simona^ORCID

Funder

International Society for Drug Development (ISDD, Milano)

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference34 articles.

1. Glioblastoma multiforme: state of the art and future therapeutics;Wilson;Surg. Neurol. Int.,2014

2. World Health Organization Classification of Tumors: Pathology and Genetic: Tumors of the Nervous System;Kleihues,2000

3. Primary brain tumours in adults;Behin;Lancet,2003

4. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial;Stupp;Lancet Oncol.,2009

5. Cancer stem cells–important players in tumor therapy resistance;Colak;FEBS J.,2014

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