Novel 5-Substituted Oxindole Derivatives as Bruton’s Tyrosine Kinase Inhibitors: Design, Synthesis, Docking, Molecular Dynamics Simulation, and Biological Evaluation-Reference-Cited by-同舟云学术

Novel 5-Substituted Oxindole Derivatives as Bruton’s Tyrosine Kinase Inhibitors: Design, Synthesis, Docking, Molecular Dynamics Simulation, and Biological Evaluation

Published:2024-02-07 Issue: Volume: Page:
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Velavalapalli Vani Madhuri¹²,Maddipati Venkatanarayana Chowdary²,Gurská Soňa³⁴,Annadurai Narendran³,Lišková Barbora³,Katari Naresh Kumar²^ORCID,Džubák Petr³⁴^ORCID,Hajdúch Marián³⁴,Das Viswanath³⁴^ORCID,Gundla Rambabu²^ORCID

Affiliation:

1. GITAM School of Pharmacy, GITAM Deemed to Be University, Hyderabad, Telangana 502329, India

2. Department of Chemistry, GITAM School of Science, GITAM Deemed to Be University, Hyderabad, Telangana 502329, India

3. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Hněvotínská 1333/5, Olomouc 77900, Czech Republic

4. Czech Advanced Technologies and Research Institute (CATRIN), Institute of Molecular and Translational Medicine, Palacký University Olomouc, Olomouc 77900, Czech Republic

Funder

Ministry of Education, Youth and Sports of the Czech Republic

GITAM University, Hyderabad

Technology Agency of the Czech Republic

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c08343

Reference39 articles.

1. Bruton’s Tyrosine Kinase and Its Isoforms in Cancer

2. Bruton tyrosine kinase inhibitors for multiple sclerosis

3. BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib

4. 1,4,6-Trisubstituted imidazo[4,5-c]pyridines as inhibitors of Bruton’s tyrosine kinase

5. Discovery of novel BTK PROTACs for B-Cell lymphomas