Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference36 articles.
1. Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function;Kurosaki;J. Biol. Chem.,1997
2. Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells;Smith;J. Immunol.,1994
3. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma;Davis;Nature,2010
4. Mechanisms of B-cell lymphoma pathogenesis;Kuppers;Nat. Rev. Cancer,2005
5. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy;Honigberg;Proc. Natl. Acad. Sci. U. S. A,2010
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