Discovery of proteolysis-targeting chimera targeting undruggable proteins using a covalent ligand screening approach
Author:
Funder
Korea Basic Science Institute
National Research Foundation of Korea
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference37 articles.
1. Targeted protein degradation: a promise for undruggable proteins;Samarasinghe;Cell Chem. Biol.,2021
2. PROTAC targeted protein degraders: the past is prologue;Békés;Nat. Rev. Drug Discov.,2022
3. Protein-protein interactions: a structural view of inhibition strategies and the IL-23/IL-17 axis;Allen;Adv. Protein Chem.Struct.Biol.,2020
4. Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs;Alabi;J. Biol. Chem.,2021
5. Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4;Lu;Chem. Biol.,2015
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