Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference69 articles.
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3. Impact of target warhead and linkage vector on inducing protein degradation: comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds;Chan;J. Med. Chem.,2018
4. Development of BromoTag: a “Bump-and-Hole”–PROTAC system to induce potent, rapid, and selective degradation of tagged target proteins;Bond;J. Med. Chem.,2021
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1. BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression;Oncogene;2024-08-20
2. A Review of the Bromodomain and Extraterminal Domain Epigenetic Reader Proteins: Function on Virus Infection and Cancer;Viruses;2024-07-08
3. Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies;Acta Pharmaceutica Sinica B;2024-02
4. BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression;2024-01-07
5. Degraders in epigenetic therapy: PROTACs and beyond;Theranostics;2024
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