Design, synthesis, and biological evaluation of novel dihydropteridone derivatives possessing oxadiazoles moiety as potent inhibitors of PLK1-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of novel dihydropteridone derivatives possessing oxadiazoles moiety as potent inhibitors of PLK1

Published:2023-05 Issue: Volume:251 Page:115242
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Li Zhiwei,Mei Sheng,Liu Jiuyu,Huang Jingxuan,Yue Hao,Ge Tingjie,Wang Kang,He Xinzi,Gu Yu-Cheng,Hu Changliang,Tong Minghui,Shi Xuan,Zhao Yanfang,Liu Yajing,Qin Mingze,Gong Ping,Hou Yunlei^ORCID

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference36 articles.

1. Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy;Strebhardt;Nat. Rev. Drug Discov.,2010

2. Inhibition of the PLK1-coupled cell cycle machinery overcomes resistance to oxaliplatin in colorectal cancer;Yu;Adv. Sci.,2021

3. Targeting cell cycle by β-carboline alkaloids in vitro: novel therapeutic prospects for the treatment of cancer;Ahmad;Chem. Biol. Interact.,2020

4. How protein kinases co-ordinate mitosis in animal cells;Ma;Biochem. J.,2011

5. Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold;Lv;Eur. J. Med. Chem.,2019

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