On-rate based optimization of structure–kinetic relationship – surfing the kinetic map
Author:
Publisher
Elsevier BV
Subject
Drug Discovery,Molecular Medicine
Reference38 articles.
1. Biochemical mechanisms of drug action: what does it take for success?;Swinney;Nat Rev Drug Discov,2004
2. Drug–target residence time and its implications for lead optimization;Copeland;Nat Rev Drug Discov,2006
3. Residence time of receptor–ligand complexes and its effect on biological function;Tummino;Biochemistry,2008
4. Pharmacokinetics and the drug–target residence time concept;Dahl;Drug Discov Today,2013
5. Can binding kinetics translate to a clinically differentiated drug? From theory to practice;Swinney;Lett Drug Des Discov,2006
Cited by 39 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. A theoretical study on the activity and selectivity of IDO/TDO inhibitors;Physical Chemistry Chemical Physics;2024
2. Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors;Purinergic Signalling;2023-07-10
3. An integrated modelling approach for targeted degradation: insights on optimization, data requirements and PKPD predictions from semi- or fully-mechanistic models and exact steady state solutions;Journal of Pharmacokinetics and Pharmacodynamics;2023-04-29
4. Allosteric binding cooperativity in a kinetic context;Drug Discovery Today;2023-02
5. Computationally Elucidating the Binding Kinetics for Different AChE Inhibitors to Access the Rationale for Improving the Drug Efficacy;The Journal of Physical Chemistry B;2022-09-28
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3