1. Fewer new drugs from the pharmaceutical industry;Taylor;BMJ,2003
2. US Department of Health and Human Services (2004) Innovation or Stagnation, Challenge and Opportunity on the Critical Path to New Medicinal Products (http://www.fda.gov/oc/initiatives/criticalpath/whitepaper.html)
3. European Commission (2005) Innovative Medicines Initiative (IMI). Strategic Research Agenda (http://europa.eu.int/comm/research/fp6/index_en.cfm?p=1_innomed)
4. Rebuilding Big Pharma's Business Model;Bain & Co.,2003
5. Rescuing drug discovery: in vivo systems pathology and systems pharmacology;Van der Greef;Nat. Rev. Drug Discov.,2005