Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain
Author:
Affiliation:
1. Division of Systems Biomedicine and Pharmacology; Leiden Academic Center for Drug Research; Leiden University; Leiden The Netherlands
2. Brains On-Line BV; Groningen The Netherlands
3. Certara QSP; Canterbury Innovation House; Canterbury UK
Publisher
Wiley
Subject
Pharmacology (medical),Modeling and Simulation
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/psp4.12370/fullpdf
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4. Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers;Danhof;Pharm. Res.,2005
5. Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics;Lange;Expert Opin. Drug Discov.,2017
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