Interpreting enzyme and receptor kinetics: keeping it simple, but not too simple

Author:

Krohn Kenneth A.,Link Jeanne M.

Publisher

Elsevier BV

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Molecular Medicine

Reference11 articles.

1. Enzyme kinetics;Segel,1975

2. Motulsky HJ, Christopoulos A. Fitting models to biological data using linear and nonlinear regression. A practical quide to curve fitting, GraphPad Software, Inc., San Diego, CA 2003, www.graphpad.com

3. The attractions of proteins for small molecules and ions;Scatchard;Annal NY Acad Sci,1949

4. The effect of radioactive contaminants on the estimation of binding parameters by Scatchard analysis;Reiman;Biochim Biophys Acta,1978

5. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction;Cheng;Biochem Pharmacol,1973

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