Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics

Author:

Dangi Bikash,Davydova Nadezhda Y.,Maldonado Marc A.,Ahire DeepakORCID,Prasad Bhagwat,Davydov Dmitri R.ORCID

Funder

NIAAA

Publisher

Elsevier BV

Subject

Molecular Biology,Biochemistry,Biophysics

Reference46 articles.

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2. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation;Zanger;Pharmacol. Ther.,2013

3. Pharmacogenetics – five decades of therapeutic lessons from genetic diversity;Meyer;Nat. Rev. Genet.,2004

4. Precision medicine and rare genetic variants;Lauschke;Trends Pharmacol. Sci.,2015

5. Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches;Venkatakrishnan;Drug Metab. Dispos.,2000

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