The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference38 articles.
1. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.
2. Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
3. ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
4. Oncogenes and signal transduction
5. An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase
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