Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response

Author:

Sargsyan Ernest,Artemenko Konstantin,Manukyan Levon,Bergquist Jonas,Bergsten Peter

Funder

European Commission

Swedish Diabetes Association

Swedish Medical Research Council

Family Ernfors Foundation

SRC

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference61 articles.

1. Obesity and free fatty acids;Boden;Endocrinol. Metab. Clin. N. Am.,2008

2. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans;Zhou;J. Clin. Endocrinol. Metab.,1995

3. Palmitate-induced impairments of beta-cell function are linked with generation of specific ceramide species via acylation of sphingosine;Manukyan;Endocrinology,2015

4. Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure;Kristinsson;Biochim. Biophys. Acta,2015

5. Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1;Maestre;Endocrinology,2003

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