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Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure

  • Published:2015-12 Issue:12 Volume:1853 Page:3248-3257
  • ISSN:0167-4889
  • Container-title:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • language:en
  • Short-container-title:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Author:

Kristinsson Hjalti,Bergsten Peter,Sargsyan Ernest

Funder

European Commission FP7-project Beta-JUDO

Swedish Diabetes Association

Family Ernfors Foundation

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference48 articles.

1. The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids;Berne;Biochem. J.,1975

2. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion;Prentki;J. Biol. Chem.,1992

3. Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells;Sargsyan;Lipids Health Dis.,2011

4. Glycerolipid metabolism and signaling in health and disease;Prentki;Endocr. Rev.,2008

5. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids;Briscoe;J. Biol. Chem.,2003
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