Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition

Author:

Boer Daphne E.C.,van Smeden Jeroen,Al-Khakany Hanin,Melnik Elizaveta,van Dijk Rianne,Absalah Samira,Vreeken Rob J.,Haenen Caroline C.P.,Lavrijsen Adriana P.M.,Overkleeft Herman S.,Aerts Johannes M.F.G.,Bouwstra Joke A.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference63 articles.

1. Barrier function of the skin: “la raison d'etre” of the epidermis;Madison;J Invest Dermatol,2003

2. “Outside-to-inside” (and now back to “outside”) pathogenic mechanisms in atopic dermatitis;Elias;J Invest Dermatol,2008

3. Inside out or outside in: does atopic dermatitis disrupt barrier function or does disruption of barrier function trigger atopic dermatitis?;Silverberg;Cutis,2015

4. The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies;Brunner;J. Allergy Clin. Immunol.,2017

5. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis;Palmer;Nat. Genet.,2006

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